Exercise response in 404 young men with asthma: no evidence for a late asthmatic reaction.

نویسنده

  • J Karjalainen
چکیده

As the existence of a late reaction in exercise induced asthma is controversial, peak expiratory flow (PEF) was measured for up to 13 hours after a running test in 404 consecutive young male army conscripts undergoing assessment of their asthma. In 294 subjects (73%) the immediate post-exercise fall in PEF was 10% or more; the mean (SD) fall in PEF in this group was 27% (15%). Nine patients with exercise induced asthma had a fall in PEF of 20% or more 4-13 hours after the exercise test. In these possible "late responders," however, the change in PEF 4-13 hours after exercise was similar to the change in PEF on control days before and after the exercise day, and the lowest PEF during this period was similar to the lowest measurements on the control days. These nine subjects showed pre-exercise bronchodilatation. Their pre-exercise PEF, from which the percentage fall in PEF was calculated, was 24% (9%) higher than the mean PEF level on control days. This study supports the view that what appears to be a "late asthmatic reaction" after exercise is an artefact. Spontaneous within day fluctuation in pulmonary function, pre-exercise bronchodilatation, and the fact that airflow obstruction persists after the early postexercise response may give a false impression of an exercise induced late asthmatic response in patients with labile airways.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Level of Nitric Oxide in Bronchoalveolar Lavage Fluid of Asthmatic Mice Model

Background: Asthma is a chronic inflammatory disease with multifactorial and complicated mechanisms. Elevated level of exhaled Nitric Oxide (NO) in asthma and other inflammatory lung diseases has led to many studies examining NO as a potential marker of airway inflammation. Objective: This study was designed to determine the level of NO in Bronchoalveolar Lavage (BAL) fluid during early and l...

متن کامل

Effects of Sodium Cromoglycate on Iranian Asthmatic Subjects Without Exposure to any Bronchoconstrictor agent

   Cromolyn sodium, a mast cell stabilizing agent, provides an immediate protective effect against the exercise-induced bronchoconstriction while being used before the exercise. However, cromolyn is ineffective in reversing asthmatic bronchospasm; it is used as a maintenance therapy and has a prophylactic role in chronic asthma.    The purpose of this study was to determine the extent of change...

متن کامل

Effects of Sodium Cromoglycate on Iranian Asthmatic Subjects Without Exposure to any Bronchoconstrictor agent

   Cromolyn sodium, a mast cell stabilizing agent, provides an immediate protective effect against the exercise-induced bronchoconstriction while being used before the exercise. However, cromolyn is ineffective in reversing asthmatic bronchospasm; it is used as a maintenance therapy and has a prophylactic role in chronic asthma.    The purpose of this study was to determine the extent of change...

متن کامل

آسم و فعالیت ورزشی ؛ یک مطالعه مروری سیستماتیک

Introduction: Asthma is a chronic inflammatory and reversible airway disease. Modification of lifestyle by increasing obesity prevalence and decreasing physical activity is one of the main cause of its rising prevalence. Patients with asthma have lower fitness than their healthy counterparts. Regular exercise improves fitness in Asthmatic patients and reduces the symptoms of the disease. Hence,...

متن کامل

Effect of nebulised salbutamol on maximal exercise performance in men with mild asthma.

The effect of 5 mg nebulised salbutamol on the cardiorespiratory responses to a progressive maximal exercise test was investigated in eight asthmatic (mean forced expiratory volume in one second (FEV1) 3.48 (1.0) litres) and eight non-asthmatic men. Exercise tests were performed on a bicycle ergometer after administration of nebulised salbutamol or matched saline placebo. In the asthmatic subje...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Thorax

دوره 46 2  شماره 

صفحات  -

تاریخ انتشار 1991